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We have developed and employed multimodal nonlinear optical microscopy to monitor the regulation of lipids in single cells and simple organisms. To address the depth limitation of nonlinear optical microscopy, we recently developed a new tool termed vibrational photoacoustic microscopy. Based on excitation of overtone vibration and acoustic detection of the generated sound waves, this method permits in situ detection of lipid-laden plaques in atherosclerosis with mm-scale penetration depth and holds great potential for diagnosis of vulnerable plaques in patients. uir;So儎v癳悇_苸迉孴uir g:gSO剉RP[b螾€b/g b霳裇U\哊(u嶯緐舥蕥璭孴籰梪剉^h皨RP[b螾s^餝惽徲殬梽v^椏~'`/c≧b螾€b/g b霳xvz哊(W N Tag鯪 N亇v(峗c$O剉:gt0)R(uo僫r}廠O剉FRETb螾 韈:y哊Z€Tir鰛抾0RLv苸迉渷剉l忹y菑 z(PNAS 2006, 103:13872, PNAS 2008, 105:6596)0購汵b螾觺済.^㏑b霳裇U\鶴鵞Y$O'` 佊歘c$O閑g頞 Y剉硚s|;So儉b/g(Nature Nano 2010, 5:80)0b霳裇U\v^瀃E枖^(u哊鵞US*N苸迉孴€{USuir g:gSO-N{|  +45;RS_tu " A C 胫胫肓泭泭泈dwdQdw>wQw%hlwWh3B*CJOJQJ^Jph"""%hlwWh?_yB*CJOJQJ^Jph"""%hlwWh ]gB*CJOJQJ^Jph"""%hlwWhe_B*CJOJQJ^Jph"""!hlwWh坿PB*OJQJ^Jph!hlwWh5B*OJQJ^Jph(hlwWh ]g5丅*CJOJQJ^Jph(hlwWh55丅*CJOJQJ^Jph(hlwWht5丅*CJOJQJ^Jph(hlwWh坿P5丅*CJOJQJ^JphSu~  24gd*y$a$gd3/)$a$gd3/)gdtgd3$a$gd9C m p w    Z  ) ; A B D E G Z ` b n €  " > 熨少熨鹅鹅顿ll伸伸Y愘愘渡顿少少YYY叮鹅 hlwWh3CJOJQJ^JaJ%hlwWh?_yB*CJOJQJ^Jph"""%hlwWh]B*CJOJQJ^Jph"""%hlwWh3B*CJOJQJ^Jph"""hB*CJOJQJ^Jph"""%hlwWhe_B*CJOJQJ^Jph"""%hlwWh9B*CJOJQJ^Jph""".  3 } ~ 024Xjn镛娃绩杽ybK<,Kh3/)h盇OJQJnHo(tHh3/)h盇OJQJnHtH,h3/)h盇B*OJQJ^JnHo(ph"""tH,h3/)h*yB*OJQJ^JnHo(ph"""tHh*y5乶Ho(tH"h3/)ht5丆JaJnHo(tH"h3/)h*y5丆JaJnHo(tH'h ]gB*CJOJQJ^JnHph"""tH!hlwWh3B*OJQJ^Jph hlwWh9CJOJQJ^JaJ hlwWh3CJOJQJ^JaJ hlwWh]CJOJQJ^JaJB\^`暧加蛹洐紓紂_q_Mf甠€b/g0:N哊銐砆^椏~'`IQf[>f甠€b/g剉駇P6R顣槝 褟gb霳蹚Nek裇U\哊 /c≧IQ餢>f甠€b/g 0鶺嶯踠憳/c≧孴a擽餢鈒剉餢f[Km€b/g 購蛓筫誰≧ 乴xlipid-laden plaques剉 in situ Km緩0R雓s|蠎剉z愸m0郪dk holds great potential for diagnosis of vulnerable plaques in patients.     灬秩兰兰兰兰h*jh*Uh3/)h盇5乶Ho(tHh*y5乶Ho(tHh3/)5乶Ho(tH%h3/)CJOJQJ^JaJnHo(tH 21恏:p廘)靶/ 班=!盃"盃#悹$悹%靶靶 愋b 666666666vvvvvvvvv6666666666666666666666666666666666666666666666666666666h6666666666666666666666666666666666666666666666666666666666666666662 0@P`p€2( 0@P`p€ 0@P`p€ 0@P`p€ 0@P`p€ 0@P`p€ 0@P`p€8XV~PJ_HmH nHsH tH8`8 qck噀CJ_HaJmH sH tH $A`$ 貫祂=刉[SOBiB 0nf恏*B*ph"W" `亯筽5乗丯"N *y0u w'$ 9r &dG$Pa$CJaJ212 *y0u w Char CJaJtH 6 B6 *y0u 9r G$CJaJ2Q2 *y0u Char CJaJtH ,a, 盇 short_textPK!倞[Content_Types].xml瑧薺0E鲄卸豶(ヘ微Iw},浔-j弰4 蛇w旄P-t#b螜{U畯銧擉T閁^h卍}悒)蛔*1P' 揯鬃W孱0)櫐T闉9<搇#ぼ$yi}佸;纞@囨(顚跄H滖男u* D谞z內/0娗盃瘥 $€ X3aZ⒁锣,癉0j~3叨蝏沩~i>赝3縗`?/[G殁\!-跼k.搒曰..椃碼婵?PK!ブх6 _rels/.rels剰蟡0 囷吔冄}Q颐%v/C/(h"脎O 劋秣=畫旂 毆免C?薶醰=偵叅%[xp啠{鄣_糚眩<10堎O糝瓸d焉襃E4b$q_槥6L吁R7`畯ㄉ趁0虨O,錏n7擫i鋌〃/鉙綈╡械根铸PK!kytheme/theme/themeManager.xml 蘉 @醹愘7c(Eb菜CA菭覠圩邈7芜諞K Y, 奺.埛饇,ㄚH,l崆骈x纱逫萻Q}#諓叚递 值+!,較$j=婫W栌)釫+& 8PK!mQtheme/theme/theme1.xml靁MoE#F{oc'vGuh覨盵糟x=逎zvg53Nj廐H垈z饴昛 $石I)*E阓酀欇鮊&IA!裎>秣羌3緓镹男>掤搁U蟇L0斈屵呖z迃rx鳔脅稔h9T8奣/魁煜?鍃Y雒'蟸3S琦棌~蜩鶅O_|w)馉镉圚t=乤+d NG1-Rl苼1諶J鴚T锠疢1Kc柩"o he浪撣幝絇L-憒%绗臙甴Y7'qP.\L姼=岟薲穛炷3I爋fi墸.帽墘BRb-J款P_p蒅 茛▍i㎏鷗郿訉h汧梚櫷o7;7Q嫵2染媱珼>a/銐翾>嶺厌W 藬霱卂膗H剄)薶 胺+:Vi豾4r態裶汐橌"r嫃!帓2l徠a麃C奲此U|嚮!8^顩8>軤仯,A魶壭眲V韙鄨讕厏ls囔14犁_=,涩返o聻TV 跥陲"苎鎎H唼灮'.4熯x薜躻-戏蹺鮸褾;氕衯踯`嘼3"G 'e\昮H柊O 话ㄩ恬愪'$劘i_wp伬 >*靺8魂i&丩Y%\铝,楎謝視=瞩伭壵阱綔 r6f 提3储淭厥厰)橗:陋ZK誏玸ゅ&C 鏜兣軟0€ [浪玴@注醏j扣7 媺耏咹唜Hi荤cT5A蕆跑@顢腍驇馴AZC硙i' RQ\m伕,zo,僩Q襲{Y\,Nψ/=溷ら嵿L _.跆嘫7C6韽-fS宄h62密"5咍麥罭H凾[X65太4X%Y龡豚殖2纅鷎h辈绅痠~tCKF#猥b +趙1m鑵4`眹!:U翞!昿5a:倊€{4韒笫m蝘o 萎c杽8m泛D矹秔S枪姗豓1铘?#S奿?3E'pS2疳W`る甸q]( ┻08樲w别 n撏A鲺[s枃)k8皓= Aa?R d趻删c楿咏瞬d)#換ueb恾满捷C!ず&i0福>4魫S7鋥z虮 F箎 4sKvUKo瘸椒h垀1砵YU€奥V蠬塔5U8錠k;譁潘鮈9堚寂皹D 荀 ?*|FL 迪鳡"A3兇伂>g类dm2iV值殍そ杕謌<殒r8[kv抶熞蠃p鎶sj,潩z伛礭[鑚堨叆Qv11縤u鈨-高0%M2羙J描3u舘%覎PK! 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